患有慢性肺炎的患者使用胰岛素的呼吸系统结果:全国基于人口的队列研究
Fu-Shun Yen1, Shu-Hao Chang2, James Cheng-Chung Wei3,4,5
1Dr. Yen's Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan 33354, Taiwan.
患有2型糖尿病和COPD的患者使用胰岛素会增加COPD恶化,肺炎,通风和低血糖的风险,但不会导致死亡. 这一发现对于管理这些复杂的条件至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2D) 和慢性阻塞性肺病 (COPD) 经常同时存在.
- 严重高血糖在COPD恶化可能需要胰岛素治疗.
研究的目的:
- 调查T2D和COPD患者使用胰岛素的风险.
- 为了比较胰岛素使用者与非使用者之间的住院,通风和死亡风险.
主要方法:
- 从台湾国家医疗保险研究数据库 (2000-2018) 中,对2370对胰岛素使用者和非使用者的倾向性得分进行匹配.
- 使用了Cox的比例危险模型和Kaplan-Meier方法进行结果比较.
主要成果:
- 胰岛素使用显著增加了COPD住院 (aHR 1.7),细菌性肺炎 (aHR 2.42),非侵入性通风 (aHR 5.05),侵入性通风 (aHR 2.72) 和严重低血糖症 (aHR 4.71) 的风险.
- 两组之间没有发现死亡风险的显著差异.
结论:
- 在T2D和COPD患者中,胰岛素治疗与恶化,肺炎,通风和严重低血糖症的风险更高有关.
- 在这个队列中,胰岛素使用并没有显著增加死亡风险.
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