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在动态微生物组模型中探索类营养药埃里奥西特林和甲胺之间的协会,以改善糖尿病前期

Thais Cesar¹, Mateus Kawata Salgaço¹, Victoria Mesa^2,3

¹Graduate Program in Food, Nutrition and Food Engineering, Campus Araraquara, São Paulo State University (UNESP), Araraquara 14800-060, SP, Brazil.

Pharmaceuticals (Basel, Switzerland)

|May 27, 2023

概括

使用Eriomin®和美特福林改善了糖尿病前期管理,通过增加有益细菌和关键脂肪酸来增强肠道微生物群. 这种组合对糖尿病前期治疗具有前景.

科学领域:

微生物学微生物学
代谢健康代谢健康
营养学科学营养学科学

背景情况:

糖尿病前期是2型糖尿病之前的代谢状态,其特点是肠道微生物群功能障碍 (失生症).
甲胺是一种常规的低血糖剂,但由于其对微生物群和葡萄糖控制的有益作用,人们寻找天然化合物.
类黄化合物混合物,如Eriomin®,在控制血糖和增加GLP-1方面显示出潜在的潜力.

研究的目的:

为了研究营养药物Eriomin®与甲胺结合对糖尿病前肠道微生物群的影响.
评估微生物组成和短链脂肪酸 (SCFA) 生产的变化.

主要方法:

使用了人类肠道微生物生态系统模拟器 (SHIME®) 模型.
接种了来自糖尿病前患者的微生物群的SHIME®.
给出了Eriomin®加上甲胺,并分析了微生物16S rRNA基因测序和SCFA生产.

主要成果:

埃里奥明®加上甲福林显著增加了酸盐和丁酸盐的产量.
微生物分析显示,刺激了 *Bacteroides* 和 *Subdoligranulum* 属的生长.
*细菌体*是SCFA生产的关键,而*亚多粒体*与改善的葡萄糖代谢有关.

结论:

在糖尿病前的模型中,eriomin®与甲福明结合,积极调节了肠道微生物群的组成和新陈代谢.
这种组合疗法表明了糖尿病前期的潜在治疗策略,解决了血糖控制和肠道健康问题.

关键词:

中的黄类固醇我们的微生物群.益生菌益生菌前生物短链脂肪酸短链脂肪酸

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