免疫媒介对COVID-19疫苗的器官特异反应:一个回顾性描述性研究
Carmen Ruiz-Fernández1, Ricardo Cuesta1, Susana Martín-López2
1Immunology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain.
Pharmaceuticals (Basel, Switzerland)
|May 27, 2023
概括
对COVID-19疫苗的延迟过敏反应 (HRs) 是罕见的. 淋巴细胞转化试验 (LTT) 在确定聚乙烯糖醇 (PEG) 和聚酸盐80 (P80) 作为这些疫苗反应的罪祸首方面表现有希望.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 临床医学 临床医学
背景情况:
- 快速开发的COVID-19疫苗可能会导致罕见的过敏反应 (HRs).
- 推迟HR被怀疑与疫苗辅助剂如聚乙烯糖醇 (PEG) 和聚酸盐80 (P80) 有关.
- 目前的诊断方法,如皮肤贴片测试,对于延迟反应是无效的.
研究的目的:
- 评估淋巴细胞转化试验 (LTT) 对诊断COVID-19疫苗辅助剂PEG和P80.0的延迟过敏反应的有用性.
- 调查LTT结果与特定类型的过敏反应之间的关联.
主要方法:
- 淋巴细胞转化测试 (LTT) 对23名怀疑对COVID-19疫苗有延迟过敏反应的患者进行.
- 测试涉及暴露于聚乙烯糖醇 (PEG) 和聚酸盐80 (P80) 的情况.
- 记录了患者的结果,包括反应类型,住院和恢复时间.
主要成果:
- 在23名患者中有8名 (34.8%) 呈阳性LTT.
- 在患有神经,肝炎和风湿反应的患者中观察到积极的LTT结果.
- 所有患有心肌炎反应的患者都显示了负的LTT结果.
结论:
- 淋巴细胞转化测试 (LTT) 似乎是识别聚乙烯糖醇 (PEG) 和聚酸盐80 (P80) 作为对COVID-19疫苗过敏反应的致病原体的宝贵工具.
- 在接种疫苗后出现过敏反应的患者中,LTT可能有助于风险分层.
相关概念视频
Allergic Drug Reactions
901
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
901
Allergic Reactions
27.9K
Overview
27.9K
Vaccinations
44.9K
Overview
44.9K
Cross-reactivity
31.4K
Overview
31.4K
Cell-mediated Immune Responses
69.2K
Overview
69.2K
Hypersensitivities
812
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
812


