SIRT1信号参与了Moringa Oleifera种子在衰老过程中诱导的血管改善
Valeria Conti1,2, Joseph Iharinjaka Randriamboavonjy3,4, Herintsoa Rafatro4
1Department of Medicine Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, S. Allende, 84081 Baronissi, SA, Italy.
Pharmaceuticals (Basel, Switzerland)
|May 27, 2023
概括
在老老老老鼠中,Moringa oleifera通过提高SIRT1活性,改善了血管功能. 这种治疗减少了氧化压力,提供了对与年龄有关的心血管功能障碍的保护.
科学领域:
- 心血管生物学心血管生物学
- 衰老的研究研究.
- 营养学科学 营养学科学
背景情况:
- 血管衰老的特点是氧化生物可用性降低,内皮功能障碍,氧化应激和炎症.
- 以前的研究表明,Moringa oleifera改善了中年老鼠的血管功能.
研究的目的:
- 为了研究SIRT1在Moringa oleifera诱导的老老鼠血管改善中的作用.
- 评估Moringa oleifera对SIRT1表达,活性和与氧化应激相关的下游目标的影响.
主要方法:
- 使用了中年维斯塔老鼠 (MAWR) 和年轻维斯塔老鼠 (YWR). MAWRs接受了标准或含有Moringa oleifera的饮食. 分析了心脏和大动脉的SIRT1和FOXO1表达,SIRT1活性和氧化应激.
- 他们使用了西斑,免疫染色,度测试和DHE光探针.
主要成果:
- 治疗Moringa oleifera增强了SIRT1表达和活性在MAWRs的心脏和大动脉.
- 莫林加叶 (Moringa oleifera) 的SIRT1激活逆转了与年龄相关的核FOXO1表达在大动脉中的增加.
- 莫林加橄花在心脏和大动脉中正常化了因年龄而产生的氧化应激.
结论:
- 莫林加橄花对与年龄相关的心血管功能障碍有保护作用.
- 增强的SIRT1功能和随后的氧化应激减少是Moringa oleifera益处的关键机制.
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