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基于囊泡的细胞外药物输送系统用于头部和部状细胞癌:系统性审查

Karolina Dżaman¹, Katarzyna Czerwaty¹

¹Department of Otolaryngology, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, Poland.

|May 27, 2023

概括

细胞外囊泡 (EVs) 有望通过帮助药物输送和调节瘤微环境来治疗头支状细胞癌 (HNSCC). 然而,研究还处于早期阶段,在EV隔离和HNSCC治疗标准化方面面临挑战.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
纳米医学是一种纳米医学.

背景情况:

头角状细胞癌 (HNSCC) 每年在全球范围内影响超过89万个人.
目前的HNSCC治疗具有显著的副作用和功能缺陷,需要新的治疗方法.

研究的目的:

系统地审查细胞外囊泡 (EVs) 在头部和部状细胞癌 (HNSCC) 治疗中的新兴应用.
总结关于在HNSCC中使用EV用于药物输送,免疫调节,诊断,基因疗法和瘤微环境调节的当前知识.

主要方法:

在PubMed/MEDLINE,Scopus,Web of Science和Cochrane数据库中进行了系统的文献搜索,截至2022年12月11日.
包括全文原始研究论文在英语. 通过修改的OHAT偏差风险评级工具来评估研究质量.
在436个确定的记录中,有18个符合纳入的条件.

主要成果:

细胞外囊泡 (EVs) 对HNSCC提供各种治疗潜力,包括向药物输送和免疫系统调节.
该审查强调了HNSCC的EV研究的早期阶段,确定了EV隔离,净化和标准化的关键挑战.

结论:

电动汽车是创新的HNSCC疗法的一个有希望的前沿,尽管仍然存在重大研究障碍.
对EV隔离和治疗方案的标准化对于HNSCC治疗中的临床转化至关重要.

关键词:

药物输送系统是药物输送系统.外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.头部和部状细胞癌瘤纳米颗粒是一种纳米粒子.

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