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Updated: Jul 29, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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在重症儿童中优化万科米辛治疗:一项人口药动力学研究,以利用新生物标志物在曲线估计下告知万科米辛区域

Kevin J Downes1,2,3,4, Athena F Zuppa1,4, Anna Sharova1,2

  • 1The Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Pharmaceutics
|May 27, 2023
PubMed
概括

在重症儿童中估计贝叶斯范科米辛AUC具有挑战性. 使用脏生物标记物的新模型,如基于cystatin C的eGFR,可以准确预测万科米辛AUC,改善治疗药物监测.

关键词:
贝叶斯估计贝叶斯估计生物标志物 生物标志物危急的疾病危急的疾病.造成脏损伤的人.儿科药理学 儿科药理学人口的药理动力学这是一种血症.

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