在2型糖尿病患者中治疗病的支柱
Jessica Kearney1, Luigi Gnudi1,2
1Department of Diabetes and Endocrinology, Guy's and St Thomas NHS Foundation Trust, London SE1 9RT, UK.
Pharmaceutics
|May 27, 2023
概括
糖尿病病是糖尿病的主要并发症,显著增加末期病和心血管风险. 本综述涵盖了预防和治疗这种疾病的五种关键疗法,旨在减少患者和社会负担.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 全球糖尿病流行病导致慢性血管并发症的增加.
- 糖尿病病 (DKD) 是末期病 (ESRD) 的主要原因,并提高心血管疾病发病率和死亡率.
- 对DKD的有效干预对于减轻其对患者和社会的重大影响至关重要.
研究的目的:
- 审查目前用于预防和治疗糖尿病病的治疗策略.
- 突出五个关键药物类别,针对DKD进展和相关心血管风险.
主要方法:
- 本综述综合了关于DKD的既定和新兴药理干预措施的信息.
- 它的重点是调节氨酸 - - ангиотензин - - 阿尔多斯特系统的药物,脂质水平,葡萄糖再吸收,隐素通路和矿物质皮质激素受体.
主要成果:
- 抑制氨酸- ангиотензин-阿尔多斯特系统的药物是DKD管理的基础.
- 类他类药物治疗脂质不良症,这是一个常见的并发症.
- -葡萄糖共载体-2抑制剂 (SGLT2i) 和类似葡萄糖的1激动剂 (GLP-1RA) 显示出显著的保护和心血管益处.
- 新型非类固醇选择性矿物质皮质体受体抗剂提供了一个新的治疗途径.
结论:
- 多种治疗类别提供了不同的机制来对抗糖尿病病.
- 结合这些药物的多方面的方法对于全面的DKD管理和减少心血管并发症至关重要.
- 对新型药物的进一步研究,如选择性矿物质皮质类受体对抗剂,有望改善患者的治疗结果.
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