相关实验视频

Updated: Jul 29, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

核心外结构的PLGA颗粒具有高度可控的托芬药物释放

Norbert Varga^1,2, Rita Bélteki^1,2, Ádám Juhász^1,2

¹MTA-SZTE Lendület "Momentum" Noble Metal Nanostructures Research Group, University of Szeged, Rerrich B. Sqr. 1, H-6720 Szeged, Hungary.

|May 27, 2023

概括

这项研究表明,通过使用像Pluronic F127和Tween20这样的稳定剂,从聚甲基-协同甘化物 (PLGA) 纳米颗粒中可控制的药物释放. 稳定剂的选择对有针对性的药物递送应用的药物保留和释放概况产生重大影响.

科学领域:

* 纳米技术的使用
* 材料科学材料科学
* 制药科学制药科学

背景情况:

* 纳米粒子 (PLGA) 被研究为药物输送系统.
* 烯 (KP) 被用作一种非类固醇抗炎药物模型.
* 稳定剂如Tween20 (TWEEN) 和Pluronic F127 (PLUR) 在粒子形成方面进行了探索.

研究的目的:

* 设计可控制药物释放的生物相容的合体载体颗粒.
* 研究稳定剂对纳米粒子结构和药物释放动力学的影响.
* 优化PLGA纳米颗粒配方,以改善药物输送.

主要方法:

*纳米沉方法用于在PLGA纳米颗粒中封装 (KP).
* 传输电子显微镜 (TEM) 用于表征核心外结构.
*优化药物度和稳定剂选择,以获得稳定的合物 (~200-210 nm的水力动力直径).

主要成果:

*成功形成了精确定义的核心纳米结构.
*封装效率 (EE%) 在14-18%之间.
*稳定剂分子量和结构显著控制了药物释放:Pluronic F127 (PLUR) 导致约20%的保留,而Tween20 (TWEEN) 则产生约70%的保留.
* 药物释放通过调整单体比率来调整PLGA水友性.

结论:

*Pluronic F127提供了固体稳定 (松),导致药物保留率降低.
*Tween20形成了一个更紧的外,导致更高的药物保留.
* 稳定剂和PLGA组合的选择为纳米载体系统中调整药物释放配置文件提供了一种多功能策略.

关键词:

在 PLGA PLGA 中.有控制释放的释放.核心外纳米载体核心外纳米载体凯托普罗芬是一种酸盐.

更多相关视频

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

相关概念视频

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...