Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

648
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
648
Drug Delivery: Overview01:16

Drug Delivery: Overview

333
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
333

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Physicochemical Aspects of Mixed Micelle Formation Between Amphiphilic Drugs and Surfactants.

International journal of molecular sciences·2026
Same author

Development and Optimization of Ionic Strength-Responsive Lipid-Polymer Hybrid Nanoparticles for Buccal Protein Delivery.

Pharmaceutics·2026
Same author

Organometallic Complexes with an Indolo[2,3-<i>c</i>]Quinoline-Derived Ligand: From Structural Features and Solution Speciation to Nanoformulation for Enhanced Therapeutic Potential.

Inorganic chemistry·2026
Same author

Understanding the Toxicity of Carbon Dots: The Role of Synthesis Variability, Surface Chemistry, and Biological Context.

International journal of molecular sciences·2026
Same author

Carbon Quantum Dot-Based Sensors: Photochemical Principles and Multimodal Applications.

Materials (Basel, Switzerland)·2026
Same author

Detailed Physicochemical Analysis of Hyaluronic Acid and Transferrin Self-Assembly To Produce Drug Carrier Colloids.

ACS omega·2025

相关实验视频

Updated: Jul 29, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.4K

核心外结构的PLGA颗粒具有高度可控的托芬药物释放.

Norbert Varga1,2, Rita Bélteki1,2, Ádám Juhász1,2

  • 1MTA-SZTE Lendület "Momentum" Noble Metal Nanostructures Research Group, University of Szeged, Rerrich B. Sqr. 1, H-6720 Szeged, Hungary.

Pharmaceutics
|May 27, 2023
PubMed
概括

这项研究表明,通过使用像Pluronic F127和Tween20这样的稳定剂,从聚甲基-协同甘化物 (PLGA) 纳米颗粒中可控制的药物释放. 稳定剂的选择对有针对性的药物递送应用的药物保留和释放概况产生重大影响.

关键词:
在 PLGA PLGA 中.有控制释放的释放.核心外纳米载体核心外纳米载体凯托普罗芬是一种酸盐.

更多相关视频

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.8K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.4K

相关实验视频

Last Updated: Jul 29, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.4K
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

10.8K
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
06:47

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

37.4K

科学领域:

  • * 纳米技术的使用
  • * 材料科学 材料科学
  • * 制药科学 制药科学

背景情况:

  • * 纳米粒子 (PLGA) 被研究为药物输送系统.
  • * 烯 (KP) 被用作一种非类固醇抗炎药物模型.
  • * 稳定剂如Tween20 (TWEEN) 和Pluronic F127 (PLUR) 在粒子形成方面进行了探索.

研究的目的:

  • * 设计可控制药物释放的生物相容的合体载体颗粒.
  • * 研究稳定剂对纳米粒子结构和药物释放动力学的影响.
  • * 优化PLGA纳米颗粒配方,以改善药物输送.

主要方法:

  • *纳米沉方法用于在PLGA纳米颗粒中封装 (KP).
  • * 传输电子显微镜 (TEM) 用于表征核心外结构.
  • *优化药物度和稳定剂选择,以获得稳定的合物 (~200-210 nm的水力动力直径).

主要成果:

  • *成功形成了精确定义的核心纳米结构.
  • *封装效率 (EE%) 在14-18%之间.
  • *稳定剂分子量和结构显著控制了药物释放:Pluronic F127 (PLUR) 导致约20%的保留,而Tween20 (TWEEN) 则产生约70%的保留.
  • * 药物释放通过调整单体比率来调整PLGA水友性.

结论:

  • *Pluronic F127提供了固体稳定 (松),导致药物保留率降低.
  • *Tween20形成了一个更紧的外,导致更高的药物保留.
  • * 稳定剂和PLGA组合的选择为纳米载体系统中调整药物释放配置文件提供了一种多功能策略.