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在阿尔茨海默氏症类型痴呆症的鼻腔药物管理:向临床应用
Raquel Taléns-Visconti1, Jesus Vicente de Julián-Ortiz2, Ofelia Vila-Busó3
1Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Valencia, Spain.
Pharmaceutics
|May 27, 2023
概括
纳米结构的脂质载体对鼻内阿尔茨海默氏症类型痴呆症 (ATD) 治疗有希望,克服了血脑屏障的挑战. 需要进一步的研究来证实这种直接向大脑输送的途径的潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 阿尔茨海默氏症类型痴呆症 (ATD) 治疗与血脑屏障的透和全身副作用作斗争.
- 鼻内通道通过嗅觉和三胞胎通道直接进入大脑,但在药物吸收和生物可用性方面面临挑战.
- 技术策略对于优化配方物理化学特征至关重要,以便有效的鼻内药物输送.
研究的目的:
- 审查纳米结构脂质载体 (NLCs) 在阿尔茨海默氏症类型痴呆症 (ATD) 治疗中用于鼻腔注射.
- 评估NLCs在克服ATD治疗的鼻内输送挑战方面的潜力.
- 总结目前对鼻内ATD治疗的临床前和临床研究.
主要方法:
- 对研究的文献综述,研究了在ATD中注入鼻腔的NLC.
- 对NLC毒性和治疗疗效的临床前数据的分析.
- 对鼻内ATD候选药物的当前临床试验状态的检查.
主要成果:
- 基于脂质的纳米系统,特别是NLC,在临床前的ATD研究中显示出具有低毒性和良好的疗效的前景.
- 在克服与鼻内药物吸收和生物可用性相关的挑战方面,NLCs显示出潜力.
- 目前,没有被批准的鼻内ATD药物,只有胰岛素,里瓦斯蒂格明和APH-1105在临床研究中.
结论:
- 纳米结构脂质载体是ATD治疗的鼻内输送的一个有希望的策略.
- 通过NLCs增强的鼻内通道对未来的ATD治疗具有显著的潜力.
- 需要继续进行研究和临床试验,以验证ATD的鼻内注射疗效.
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