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相关概念视频

Drug Delivery: Overview01:16

Drug Delivery: Overview

333
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
333
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

409
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
409
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

648
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
648
Pharmacovigilance01:19

Pharmacovigilance

916
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
916
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

528
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
528

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相关实验视频

Updated: Jul 29, 2025

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
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眼部药物输送的实时监控平台

Sahar Awwad1,2,3, Nkiruka Ibeanu1,2,3, Tianyang Liu1,2

  • 1Optceutics Ltd., 28a Menelik Road, London NW2 3RP, UK.

Pharmaceutics
|May 27, 2023
PubMed
概括
此摘要是机器生成的。

一个新的实时监测平台,PK-EyeTM,已开发用于体外人眼药物测试. 该系统可实现并行药物表征和质量控制,推进临床前眼部配方评估.

关键词:
自动化自动化自动化自动化度探测器的度探测器微流体学 在微流体学方面眼球 眼球 眼球眼科 眼科 眼科药品测试 药品测试 药品测试 药品测试实时监控实时监控萨卡德斯 (saccades) 是一个古老的书.

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科学领域:

  • 生物医学工程 生物医学工程
  • 眼科医生 眼科 眼科
  • 药理动力学 药理动力学

背景情况:

  • 实时测量对于药物表征和溶解测试中的质量控制至关重要.
  • 现有的体外模型往往缺乏人类眼睛的动态生理条件.

研究的目的:

  • 开发和验证与体外人眼模型 (PK-EyeTM) 集成的实时监测平台.
  • 评估平台在平行药物表征,质量控制和眼镜配方临床前测试方面的能力.

主要方法:

  • 开发一个微流体系统,带有传感器的眼动平台和度探针设置.
  • 使用"冲刺模型"来确定表面膜的透性.
  • 实现并行微流体控制,以提高可扩展性和可重复性.
  • 整合了一个昼夜节律程序,用于水性幽默流动模拟.
  • 验证的眼内压力 (IOP) 和水性幽默流速模拟.

主要成果:

  • 在PK-EyeTM模型中通过优化孔径大小和表面积来达到生理眼内压力 (IOP).
  • 证明了压力流动力学的可扩展性和可重复性.
  • 成功模拟了水性幽默流速的日间变化.
  • 记录了Alexaalbumin的实时度监测,显示了恒定的释放概况.
  • 验证了平台复制编程眼动的能力.

结论:

  • 开发的PK-EyeTM平台可以实时监控眼睛配方的临床前测试.
  • 该系统提供了一个可扩展和可重复的方法,用于在体外评估药物释放和眼睛生理学.
  • 这项技术促进了眼科产品的并行药物表征和质量控制.