眼部药物输送的实时监控平台
Sahar Awwad1,2,3, Nkiruka Ibeanu1,2,3, Tianyang Liu1,2
1Optceutics Ltd., 28a Menelik Road, London NW2 3RP, UK.
Pharmaceutics
|May 27, 2023
概括
一个新的实时监测平台,PK-EyeTM,已开发用于体外人眼药物测试. 该系统可实现并行药物表征和质量控制,推进临床前眼部配方评估.
科学领域:
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
- 药理动力学 药理动力学
背景情况:
- 实时测量对于药物表征和溶解测试中的质量控制至关重要.
- 现有的体外模型往往缺乏人类眼睛的动态生理条件.
研究的目的:
- 开发和验证与体外人眼模型 (PK-EyeTM) 集成的实时监测平台.
- 评估平台在平行药物表征,质量控制和眼镜配方临床前测试方面的能力.
主要方法:
- 开发一个微流体系统,带有传感器的眼动平台和度探针设置.
- 使用"冲刺模型"来确定表面膜的透性.
- 实现并行微流体控制,以提高可扩展性和可重复性.
- 整合了一个昼夜节律程序,用于水性幽默流动模拟.
- 验证的眼内压力 (IOP) 和水性幽默流速模拟.
主要成果:
- 在PK-EyeTM模型中通过优化孔径大小和表面积来达到生理眼内压力 (IOP).
- 证明了压力流动力学的可扩展性和可重复性.
- 成功模拟了水性幽默流速的日间变化.
- 记录了Alexaalbumin的实时度监测,显示了恒定的释放概况.
- 验证了平台复制编程眼动的能力.
结论:
- 开发的PK-EyeTM平台可以实时监控眼睛配方的临床前测试.
- 该系统提供了一个可扩展和可重复的方法,用于在体外评估药物释放和眼睛生理学.
- 这项技术促进了眼科产品的并行药物表征和质量控制.
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