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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
348

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通过表面修饰来优化无形固体分散辅助剂粉体的批量流量.

Danni Suhaidi1, Yao-Da Dong2, Paul Wynne3

  • 1School of Engineering, Deakin University, Waurn Ponds, VIC 3216, Australia.

Pharmaceutics
|May 27, 2023
PubMed
概括

对于许多辅助剂来说,L-氨酸共处理提高了无形固体分散 (ASD) 粉末的流动性. 这项研究研究了L-leucine.

关键词:
这是一种L-leucine.无形固体分散的分散.散装粉末的特征描述增强流动性 增强流动性粒子工程是什么?粒子工程是什么?喷雾干燥 喷雾干燥表面的修改表面的修改

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 无形固体分散 (ASDs) 在固体剂型中增强药物的口服生物可用性和宏分子稳定性.
  • 喷雾干燥的ASD表现出表面凝聚力和高度,对粉末流动和加工产生负面影响.
  • 表面修改对于改善ASDs的散装特性至关重要.

研究的目的:

  • 研究L-leucine (L-leu) 共处理在改变ASD形成材料的颗粒表面的有效性.
  • 评估L-leu对各种原型ASD助剂的散装特性和流动性的影响.
  • 了解L-leu在与不同聚合物共同配制时的机械行为.

主要方法:

  • 与各种原型ASD辅助剂共同处理L-氨酸,包括马尔托德克斯,聚烯 (PVP K10和K90),三糖,阿拉伯和基甲基纤维素 (HPMC E5LV和K100M).
  • 在受控条件下喷雾干燥,以尽量减少颗粒大小对凝聚力的影响.
  • 使用扫描电子显微镜 (SEM) 的形态评估.
  • 散装粉末的特征化使用粉末风力计来评估流动性,流速灵敏度和紧缩性.

主要成果:

  • 通过L-氨酸的共同处理,通常可以提高马尔托德素,PVP K10,三糖和阿拉伯配方的流动性.
  • 扫描电子显微镜揭示了粒子表面的已知和新的形态变化.
  • 聚烯利 K90 和基甲基纤维素配方提出了独特的挑战,为L-leucine的机械行为提供了洞察力.

结论:

  • 氨酸是一种有效的辅助剂,可以改善某些无形固体分散物的粉末流动特性.
  • 建议进行进一步的研究,以探索L-氨酸与配方辅助剂的物理化学特性之间的相互作用.
  • 需要增强的批量表征工具,以充分理解L-氨酸表面修饰的多因素影响.