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通过表面修饰来优化无形固体分散辅助剂粉体的批量流量

Danni Suhaidi¹, Yao-Da Dong², Paul Wynne³

¹School of Engineering, Deakin University, Waurn Ponds, VIC 3216, Australia.

|May 27, 2023

概括

对于许多辅助剂来说,L-氨酸共处理提高了无形固体分散 (ASD) 粉末的流动性. 这项研究研究了L-leucine.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
化学工程是化学工程的重要组成部分.

背景情况:

无形固体分散 (ASDs) 在固体剂型中增强药物的口服生物可用性和宏分子稳定性.
喷雾干燥的ASD表现出表面凝聚力和高度,对粉末流动和加工产生负面影响.
表面修改对于改善ASDs的散装特性至关重要.

研究的目的:

研究L-leucine (L-leu) 共处理在改变ASD形成材料的颗粒表面的有效性.
评估L-leu对各种原型ASD助剂的散装特性和流动性的影响.
了解L-leu在与不同聚合物共同配制时的机械行为.

主要方法:

与各种原型ASD辅助剂共同处理L-氨酸,包括马尔托德克斯,聚烯 (PVP K10和K90),三糖,阿拉伯和基甲基纤维素 (HPMC E5LV和K100M).
在受控条件下喷雾干燥,以尽量减少颗粒大小对凝聚力的影响.
使用扫描电子显微镜 (SEM) 的形态评估.
散装粉末的特征化使用粉末风力计来评估流动性,流速灵敏度和紧缩性.

主要成果:

通过L-氨酸的共同处理,通常可以提高马尔托德素,PVP K10,三糖和阿拉伯配方的流动性.
扫描电子显微镜揭示了粒子表面的已知和新的形态变化.
聚烯利 K90 和基甲基纤维素配方提出了独特的挑战,为L-leucine的机械行为提供了洞察力.

结论:

氨酸是一种有效的辅助剂,可以改善某些无形固体分散物的粉末流动特性.
建议进行进一步的研究,以探索L-氨酸与配方辅助剂的物理化学特性之间的相互作用.
需要增强的批量表征工具,以充分理解L-氨酸表面修饰的多因素影响.

关键词:

这是一种L-leucine.无形固体分散的分散.散装粉末的特征描述增强流动性增强流动性粒子工程是什么?粒子工程是什么?喷雾干燥喷雾干燥表面的修改表面的修改

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