3D打印技术作为设计基于纳米医学的固体剂量形式的有希望的工具:当代研究和未来范围
Javed Ahmad1, Anuj Garg2, Gulam Mustafa3
1Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia.
Pharmaceutics
|May 27, 2023
概括
3D打印可以从纳米药物中创建个性化的固体剂型. 这项技术将液态纳米药物配方转化为固体药片和假药,克服了制造方面的挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 纳米技术纳米技术
- 3D打印应用 3D打印应用
背景情况:
- 3D打印正在彻底改变制药制造业,使复杂的剂量形式成为可能.
- 将纳米药物整合到固体剂型中,带来了重大制剂挑战.
- 个性化医疗需要灵活和高效的制造量身定制的药物输送系统.
研究的目的:
- 审查基于纳米医学的固体剂型3D打印的最新进展.
- 利用3D打印探索液态纳米载体转化为固体剂型的过程.
- 分析过程参数对3D打印纳米医药配方性能的影响.
主要方法:
- 对用于制药应用的3D打印技术 (例如,FDM,PAM) 的当前研究进行审查.
- 对聚合物纳米囊和自我纳米乳化药物输送系统 (SNEDDS) 等纳米药品结合研究的分析.
- 评估影响3D打印固体剂型质量和性能的过程参数.
主要成果:
- 3D打印成功地将液体纳米药物配方 (纳米囊,SNEDDS) 转化为固体剂型 (片剂,支架).
- 基于挤出的3D打印技术有助于生产定制的固体剂型,用于口服和直肠输送.
- 通过纳米药物的3D打印,可以实现个性化的剂量和改进的药物输送.
结论:
- 3D打印为制造基于纳米医学的先进固体剂型提供了可行和灵活的平台.
- 这项技术解决了开发固态纳米药物的关键挑战,为个性化医疗铺平了道路.
- 对流程优化的进一步研究对于最大限度地发挥3D打印纳米药物的潜力至关重要.
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