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Updated: Jul 29, 2025

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
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使用生理学基础的药代动力学 (PBPK) 建模预测人类牛奶中的药物度的通用工作流程-来自 ConcePTION 项目的贡献

Nina Nauwelaerts1, Julia Macente1, Neel Deferm1,2

  • 1Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.

Pharmaceutics
|May 27, 2023
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型可以预测母乳中的药物度. 这项研究开发了一种通用的PBPK工作流程,以评估早期药物开发期间母乳养婴儿的产妇药物安全性.

关键词:
母乳养 哺乳期 母乳养每日婴儿剂量 婴儿剂量人类牛奶是人类的牛奶.在的中.哺乳期 哺乳期 哺乳期这些药物是药品.牛奶与血的比率 (M/P比率)药物动力学 药物动力学基于生理学的药理动力学 (PBPK) 建模和仿真.相对婴儿剂量相对婴儿剂量.

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