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提供化学疗法剂和核酸与pH依赖纳米颗粒的输送

Qixin Leng¹, Zuha Imtiyaz¹, Martin C Woodle²

¹Department of Pathology, University Maryland School of Medicine, University of Maryland, 10 S. Pine St., Baltimore, MD 21201, USA.

|May 27, 2023

概括

响应pH的纳米颗粒通过积聚在酸性瘤环境中提供向的癌症治疗. 这些策略在瘤中释放化疗药物,显示出有前途,但面临临临床使用的发展障碍.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

系统性纳米粒子输送到瘤是低效的 (<1%).
瘤微环境 (细胞外基质和内体) 呈现酸性pH值 (分别为6.8和5).
这种pH梯度为有针对性的纳米粒子积累和药物释放提供了机会.

研究的目的:

审查针对癌症治疗的pH响应纳米粒子策略.
探索基于瘤酸度释放药物的机制.
评估这些方法的临床前疗效和临床限制.

主要方法:

从聚合物纳米粒子和宏分子中对pH依赖的药物释放策略的审查.
对pH敏感连接,纳米粒子质子化/破坏和聚合物屏蔽机制的分析.
对抗瘤疗效的临床前数据的评估.

主要成果:

响应pH的纳米颗粒显示出由于酸性环境而增强瘤积累.
各种策略有效地在瘤细胞内释放化疗和核酸.
在临床前试验中观察到显著的抗瘤疗效.

结论:

响应pH的纳米粒子系统显示了针对癌症治疗的潜力.
利用瘤酸度是一种可行的药物输送策略.
需要进一步发展,以克服临床翻译的障碍.

关键词:

运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商运营商化学疗法化疗化疗纳米颗粒是一种纳米粒子.核酸是核酸中的一种.对于pH值敏感的物质聚合物是一种聚合物.siRNA 是一个RNA.瘤pH值瘤的pH值

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