一个新型的半固体自乳化配方的阿普雷皮坦口服:一个体外评估
Hakan Nazlı1, Burcu Mesut2, Özlem Akbal-Dağıstan2
1Department of Pharmaceutical Technology, Trakya University, 22030 Edirne, Turkey.
Pharmaceutics
|May 27, 2023
概括
这项研究开发了一种新的,具有成本效益的自我乳化药物输送系统,用于阿普雷皮坦,NK1受体对抗剂,改善其溶解性和生物可用性,用于抗治疗.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 阿普雷皮坦是一种NK1受体对抗剂,对于控制化疗引起的恶心和吐至关重要.
- 阿普雷皮坦的溶解性较差限制了其生物可用性,需要先进的配方.
- 目前的纳米晶体配方是有效的,但由于复杂的制造成本昂贵.
研究的目的:
- 开发一种替代的,具有成本效益的阿普雷皮坦配方.
- 为了增强阿普雷皮坦的溶解性和生物可用性.
- 创建一种自我乳化配方,以改善药物输送.
主要方法:
- 使用CapryolTM 90,Kolliphor® CS20,Transcutol® P和Soluplus®,设计了一种自我乳化药物输送系统 (SEDDS).
- 配方的表征涉及DLS,FTIR,DSC和XRPD. 配方的表征涉及DLS,FTIR,DSC和XRPD.
- 试验室研究包括对Caco-2细胞的脂解,溶解和细胞毒性测定.
主要成果:
- 优化的SEDDS配方证明了药物溶解率的提高.
- 脂解测试预测了有利的胃肠道消化性能.
- 细胞毒性研究表明,开发的配方具有较低的毒性.
结论:
- 成功开发了一种具有成本效益的阿普雷皮坦自乳化配方.
- 新配方显著改善了药物的溶解性和溶解性.
- 这种方法为现有的阿普雷皮坦纳米晶配方提供了一个有希望的替代方案.
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