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无形固体分散水界面层的热力学建模及其对释放机制的影响

Stefanie Dohrn1, Samuel O Kyeremateng1, Esther Bochmann1

  • 1AbbVie Deutschland GmbH & Co. KG, Global Pharmaceutical R&D, Knollstraße, D-67061 Ludwigshafen am Rhein, Germany.

Pharmaceutics
|May 27, 2023
PubMed
概括

这项研究解释了药物负载如何通过建模凝层行为来影响无形固体分散 (ASD) 释放. 热力学预测准确地预测由于ASD/水接口的结晶或相分离而导致的释放损失 (LoR).

关键词:
在PC-SAFT中使用.无形固体分散 (ASD) 的方法药物释放释放药物释放药物释放的时间逃生玻璃过渡 (eGT) 的情况液-液相分离 (LLPS) 是一种液相分离技术.阶段行为 阶段行为

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