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Updated: Jun 16, 2026

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使用自然深度修养系统作为眼睛应用的替代媒介

Célia Sarmento1, Hugo Monteiro1, Alexandre Paiva1

  • 1LAQV-REQUIMTE, Chemistry Department, NOVA-School of Science and Technology, 2829-516 Caparica, Portugal.

Pharmaceutics
|May 27, 2023
PubMed
概括

由于其粘度和生物相容性,天然深层水系统 (NADES) 对眼滴配方具有前景. 这些系统增强了药物溶解度,如乙胺,以改善青光眼的治疗.

关键词:
乙醇胺的使用方法其他替代溶剂 替代溶剂生物相容性的生物相容性药物输送是药物输送的过程.天然的深层欧特克系统.眼睛配方 眼睛配方

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...