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相关概念视频

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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使用自然深度修养系统作为眼睛应用的替代媒介.

Célia Sarmento1, Hugo Monteiro1, Alexandre Paiva1

  • 1LAQV-REQUIMTE, Chemistry Department, NOVA-School of Science and Technology, 2829-516 Caparica, Portugal.

Pharmaceutics
|May 27, 2023
PubMed
概括

由于其粘度和生物相容性,天然深层水系统 (NADES) 对眼滴配方具有前景. 这些系统增强了药物溶解度,如乙胺,以改善青光眼的治疗.

科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 生物技术是生物技术.

背景情况:

  • 眼部药物输送面临着药物保留和溶解性的挑战.
  • 天然深层水系统 (NADES) 提供可调整的物理化学特性.
  • 高粘度的NADES可能会提高眼睛的药物保留时间.

研究的目的:

  • 研究NADES作为眼睛配方的新媒体的潜力.
  • 为了对眼滴相关的rheological和物理化学性质进行NADES的表征.
  • 评估NADES提高眼药物的可溶性和生物相容性的能力.

主要方法:

  • 各种NADES配方的制备和表征.
  • 风病学和物理化学性质分析 (粘度,度,pH,接触角,折射率).
  • 使用乙醇胺 (ACZ) 的溶解性研究和ARPE-19细胞的细胞毒性测定.

主要成果:

  • 优化的NADES溶液 (5-10% w/v) 呈现出适当的粘度 (0.8-1.2 mPa.s),度 (412-1883 mOsmol) 和pH (7.4).
  • 纳德斯 (NADES) 增加了阿扎胺的溶解度高达3倍.
  • NADES证明了生物相容性,在5% (w/v) 度下维持了80%以上的细胞活力,在加入ACZ时没有增加细胞毒性.
关键词:
乙醇胺的使用方法其他替代溶剂 替代溶剂生物相容性的生物相容性药物输送是药物输送的过程.天然的深层欧特克系统.眼睛配方 眼睛配方

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结论:

  • NADES是眼睛配方的可行候选者,可以改善药物的溶解性和保留性.
  • 生物相容的NADES配方为增强眼部药物递送提供了一个有希望的方法.
  • 对基于NADES的眼睛配方的进一步研究可能会导致更有效的青光眼治疗方法.