通过三轴电旋转来改进对结肠向药物输送的工程贝珠在线纤维
Yaoyao Yang1, Wei Chen1, Menglong Wang1
1School of Materials & Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Polymers
|May 27, 2023
概括
新的串串珠 (BOTS) 微纤维提供有针对性的结肠药物输送. 这些含有聚乙烯氧化物 (PEO) 和黄 (CUR) 的糖涂层纤维防止药物过早释放,并在肠道中提供受控的零顺序释放.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 针对结肠的药物输送对于有效治疗结肠疾病至关重要.
- 电纤维为先进的药物输送应用提供了独特的结构优势.
研究的目的:
- 开发新的串珠微纤维 (BOTS) 微纤维,用于对结肠向输送黄素 (CUR).
- 研究BOTS微纤维结构与其药物释放特性之间的关系.
主要方法:
- 使用聚乙烯氧化物 (PEO),黄素 (CUR) 和雪兰进行修改的三轴电.
- 使用扫描电子显微镜 (SEM),传输电子显微镜 (TEM),X射线衍射 (XRD) 和红外光谱 (IR) 进行表征.
- 在模拟的胃和肠液中进行体外药物释放研究.
主要成果:
- 成功制造了具有核心外结构的BOTS微纤维.
- 在纤维内确认了CUR的无形状态和良好的组件兼容性.
- 证明结肠向分娩具有零顺序药物释放,防止在模拟胃液中过早释放.
结论:
- 用贝制造的BOTS微纤维提供了有效的结肠向药物输送.
- 独特的珠子结构充当储,使肠道中持续的零顺序释放成为可能.
- 这种方法提高了药物的疗效,并最大限度地减少了对结肠疾病治疗的全身暴露.
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