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增强Pullulan软囊用糖和比醇增塑剂的混合物:一个多维研究
Kecheng Zhou1,2, Yucheng Yang1,2,3, Bingde Zheng1,2
1College of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Polymers
|May 27, 2023
概括
一种酸盐和甘油增塑剂混合物改善了植物性软囊的性能. 最佳的15:15比率增强了物理化学特性,并符合Pullulan软囊的药典标准.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 塑化剂对于植物性软囊是必不可少的.
- 通过单一的塑化剂来达到所需的质量是困难的.
研究的目的:
- 为了研究比醇-甘油增塑剂混合物对普鲁兰软膜和囊性能的影响.
- 为了确定增强囊性能的最佳比率.
主要方法:
- 普鲁兰薄膜和囊的多尺度分析.
- 热重力测量分析 (TGA).
- 福里埃变换红外光谱学 (FTIR).
- 在X射线衍射 (XRD).
- 扫描电子显微镜 (SEM) 扫描电子显微镜.
主要成果:
- 与单个增塑剂相比,增塑剂混合物显著提高了普鲁兰膜/囊的性能.
- 混合物增强了相容性和热稳定性,没有化学变化.
- 索尔比特与甘油 (S/G) 的比率为15:15,产生了最佳的物理化学特性.
结论:
- 酸盐-甘油混合物比单个塑化剂更有效,用于pullulan软囊.
- 最佳的15:15 S/G比符合中国药典关于脆性和分解的要求.
- 这项研究为植物软囊提供了一个有希望的配方.
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