通过使用Sol-Gel工艺获得的Titanium与聚尿素-尿素的混合化来调整/调整聚尿素的特性
Dulce María González-García1, Luis María Rodríguez-Lorenzo2, Ángel Marcos-Fernández2
1Department of Metallurgy and Materials Engineering, ESIQIE, Instituto Politécnico Nacional, Mexico City 07738, Mexico.
Polymers
|May 27, 2023
概括
结合聚尿素和的新混合材料显示出增强的机械性能和改善的细胞活力. 这些-聚-尿素-尿混合材料是非细胞毒性,表明生物医学应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 聚合物化学 聚合物化学
背景情况:
- 混合材料结合有机和无机成分,以获得增强的性能.
- 聚尿素提供弹性和生物降解性,而提供良好的生物反应.
- 将这些材料结合起来,可以为各种应用带来具有改进特性的新物质.
研究的目的:
- 通过经过修改的sol-gel方法,利用聚urea-urethane和titania合成I类混合材料.
- 描述由此产生的混合材料的结构性,机械性,热性和降解性.
- 评估这些混合材料的体外细胞毒性,以评估其潜在的生物医学用途.
主要方法:
- 改进的sol-gel方法用于混合材料合成.
- 用FT-IR和拉曼光谱进行结构分析 (键,Ti-OH组).
- 维克尔硬度,热重力测量分析 (TGA),差分扫描热量测量 (DSC) 和水解降解试验用于性能评估.
- 在体外细胞毒性测试使用骨质细胞.
主要成果:
- 通过FT-IR和拉曼光谱学证实了-聚-尿素-尿混合材料的成功合成.
- 与纯聚合物相比,维克尔硬度增加了20%.
- 增强了表面的水友性,从而提高了细胞活力.
- 材料表现出可调节的机械和热性能以及可控制的可降解性.
- 在体外试验表明混合材料的非细胞毒性行为.
结论:
- 经过修改的sol-gel方法有效地产生了-聚-尿素-尿氨酸混合材料.
- 混合化显著提高了机械性能 (硬度) 和表面的水友性.
- 开发的混合材料显示出有希望的生物相容性和生物医学应用的潜力,因为它们的非细胞毒性.
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