作为影响生物活性物质释放率的因素,粉膜的破坏是影响生物活性物质释放率的因素
Ekaterina Podgorbunskikh1, Timofei Kuskov1,2, Anna Matveeva1
1Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze Str., 630090 Novosibirsk, Russia.
Polymers
|May 27, 2023
概括
从粉膜中释放的旋转探针取决于晶体结构. 氧化物基影响膜形态和水含量,影响可生物降解材料中的物质释放动力学.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学是一种材料科学.
- 生物材料是一种生物材料.
背景情况:
- 研究了具有不同晶体结构 (A,B,C) 和乱的粉膜.
- 研究了自旋探头 (氧化基) 释放动态.
- 使用电子磁共振 (EPR) 来分析该系统.
研究的目的:
- 为了研究粉晶体结构和乱对自旋探头释放的影响.
- 了解氧化物激素在薄膜形态和特性中的作用.
- 阐明生物降解粉薄膜中物质释放的机制.
主要方法:
- 制造具有受控晶体结构和混乱的粉薄膜.
- 电子偏磁共振 (EPR) 谱学用于自旋探头分析.
- 扫描电子显微镜 (SEM) 用于膜形态学.
- 用X射线衍射 (XRD) 来确定结晶性和晶体结构.
- 对物质释放的动态建模.
主要成果:
- 氧化物激素显著影响膜形态,导致额外的障碍和减少结晶性.
- 粉膜呈现出再结晶,A型和C型结构转变为B型结构.
- 在氧化物激素附近的局部导电性表明水度增加.
- 旋转探测器的移动性表明一个高度固定状态.
- 物质的释放遵循了两阶段的过程:由粉晶体类型影响的矩阵膨胀和扩散.
结论:
- 氧化物激素改变了粉膜的结构和特性,影响了水的分布和自旋探针的移动性.
- 从可生物降解的粉膜中释放的物质是一个复杂的过程,取决于矩阵膨胀和扩散,由原生粉晶体结构调节.
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