在HIV感染患者中SARS-CoV-2疫苗接种的有效性和安全性-现实世界研究
Monika Bociąga-Jasik1,2, Martyna Lara2, Aleksandra Raczyńska2
1Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Vaccines
|May 27, 2023
概括
在艾滋病毒感染者 (PLWH) 中,COVID-19疫苗是安全有效的. 在这个高危人群中,mRNA疫苗,特别是mRNA-1273,诱导了最强的幽默和细胞免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 在高风险人群中评估COVID-19疫苗免疫性,如艾滋病毒感染者 (PLWH) 是至关重要的.
- 生物医学研究在COVID-19疫苗开发方面取得了重大成功,但挑战仍然存在.
研究的目的:
- 评估COVID-19疫苗在艾滋病毒感染者 (PLWH) 中的免疫性和安全性.
- 为了比较PLWH中不同COVID-19疫苗类型诱导的幽默和细胞免疫反应.
主要方法:
- 121名18岁以上的PLWH被纳入波兰国家疫苗接种计划.
- 使用ELISA对抗SARS-CoV-2 S1蛋白的IgG抗体进行了口腔免疫评估.
- 用干扰素-释放试验 (IGRA) 来量化干扰素- (IFN-γ) 来测量细胞免疫力.
主要成果:
- 95% (78.5%) 的接种疫苗的PLWH开发了保护性IgG抗体水平.
- 只有6.6%的PLWH没有产生细胞免疫反应.
- 与其他疫苗相比,mRNA-1273疫苗表现出最佳的幽默和细胞免疫反应.
结论:
- COVID-19疫苗是免疫原和安全的人生活与艾滋病毒 (PLWH).
- mRNA疫苗,特别是mRNA-1273,与PLWH中优越的幽默和细胞免疫反应有关.
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