成年人的肺炎球菌疫苗接种:个性化决策考虑的叙述性审查
1Department of Medicine, National University Hospital, Singapore 119228, Singapore.
Vaccines
|May 27, 2023
概括
肺炎球菌疫苗可以预防儿童和成人的严重疾病. 本综述探讨了超出目前有限指南的个性化成人疫苗接种策略的因素.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 肺炎球菌病导致所有年龄组的显著发病率和死亡率.
- 目前的肺炎球菌疫苗 (多糖和合) 覆盖了20多种血清型.
- 现有的成年人疫苗接种指南有限,缺乏个体患者的重点.
研究的目的:
- 确定和讨论针对成人个性化肺炎球菌疫苗接种决策的考虑因素.
- 要突出超出当前优化成人肺炎球菌免疫接种指南的因素.
- 为个人制定预防严重肺炎球菌病的策略提供信息.
主要方法:
- 对现有文献和指导方针进行叙述性审查.
- 识别和综合影响个性化疫苗决策的因素.
- 讨论临床,免疫学和流行病学方面的考虑.
主要成果:
- 针对个性化的成人肺炎球菌疫苗接种,有几个因素至关重要.
- 考虑因素包括个体疾病风险,疫苗免疫性和临床疗效.
- 粘膜免疫,群体免疫,疫苗衰退和菌株替代也很重要.
结论:
- 对于成年人肺炎球菌疫苗接种,需要个性化决策.
- 考虑多种因素的综合方法可以提高疫苗的有效性.
- 优化成年人疫苗接种策略需要超越当前通用推.
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