对抗SARS-CoV-2疫苗在患有过敏反应高风险的患者中的脱敏协议
Maria Rita Messina1, Carlotta Crisciotti1, Laura Pellegrini1
1Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Vaccines
|May 27, 2023
概括
对严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 疫苗的过敏反应可能会阻碍疫苗接种完成. 脱敏方案为有过往对SARS-CoV-2疫苗过敏反应的患者提供安全有效的解决方案.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 过敏和临床免疫学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 疫苗对于预防感染和减少严重后果至关重要.
- 对SARS-CoV-2疫苗的过敏反应,虽然很少见,但可能导致不完整的疫苗接种系列.
- 其他疫苗的现有脱敏协议得到了验证,但它们对SARS-CoV-2疫苗的应用是事.
研究的目的:
- 评估对 SARS-CoV-2 疫苗出现过敏反应的患者的脱敏方案的安全性和有效性.
- 为常用的SARS-CoV-2疫苗提出标准化的脱敏协议.
主要方法:
- 对30名有过敏反应史的患者对SARS-CoV-2疫苗或其组件进行了回顾性分析.
- 对这些患者进行脱敏方案的管理.
- 在脱敏过程中监测过敏反应症状.
主要成果:
- 在研究的队列中,被发现无敏化方案是有效和安全的.
- 在30名患者中,只有2名在脱敏过程中出现过敏反应症状.
- 这项研究提供了证据,支持对SARS-CoV-2疫苗过敏的脱敏感化.
结论:
- 脱敏是一种可行且安全的策略,用于那些经历过SARS-CoV-2疫苗过敏反应的患者.
- 拟议的协议可以促进过敏问题的个体完成疫苗接种.
- 进一步研究和验证这些协议是有必要的,以支持广泛的临床采用.
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