通过重复接种疫苗诱导的IgG4抗体可能会对SARS-CoV-2尖端蛋白产生免疫耐受性
Vladimir N Uversky1, Elrashdy M Redwan2,3, William Makis4
1Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
最近的COVID-19 mRNA疫苗可能导致免疫力下降和频繁的再感染. 接种疫苗后IgG4抗体水平升高可能表明免疫耐受性,可能促进感染和自身免疫风险.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- mRNA COVID-19疫苗的快速开发和全球推广是前所未有的.
- 广泛的疫苗接种已经实现了高覆盖率,但人们仍然担心免疫力下降和突破性感染.
- 新出现的数据表明,在接受多剂量mRNA疫苗的个体中,免疫球蛋白G4 (IgG4) 的水平升高.
研究的目的:
- 为了研究mRNACOVID-19疫苗接种后IgG4抗体水平增加的影响.
- 探索IgG4诱导背后的潜在机制及其对对SARS-CoV-2免疫反应的影响.
- 评估与IgG4升高相关的潜在风险,包括免疫耐受性,减少抗病毒反应和自身免疫性疾病.
主要方法:
- 审查关于mRNA疫苗技术和免疫反应的现有文献.
- 分析报告疫苗接种后IgG4水平的研究.
- 在不同的疫苗平台和疫苗接种计划中比较IgG4诱导模式.
主要成果:
- 重复的mRNA疫苗接种,特别是高剂量的抗原,与IgG4抗体水平的显著增加有关.
- 升高的IgG4可能代表免疫耐受机制,而不是对尖端蛋白的保护性反应.
- 这种免疫耐受性可能会促进SARS-CoV-2的复制,并阻碍自然抗病毒免疫力.
- 增加IgG4合成还与自身免疫性疾病的潜在风险和其他敏感个体的不良影响有关.
结论:
- 在mRNA疫苗接种后IgG4抗体的增加需要进一步调查其免疫后果.
- 升高的IgG4可能会通过促进免疫耐受性和可能增加感染易感性来损害疫苗的疗效.
- 为了了解重复mRNA疫苗接种的长期安全性和免疫调节效应,特别是关于自身免疫风险的进一步研究至关重要.
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