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疫苗接种对血小板线粒体生物能量功能的影响患有后急性COVID-19的患者的功能

Anna Gvozdjáková¹, Jarmila Kucharská¹, Zuzana Rausová¹

¹Pharmacobiochemical Laboratory of 3rd Medical Department, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.

|May 27, 2023

概括

预防性疫苗接种保护了后急性COVID-19患者的血小板线粒体功能. 然而,接种疫苗并没有恢复内源性辅酶Q10 (CoQ10) 水平,这表明需要进一步研究针对性COVID-19疗法.

科学领域:

生物化学生化学
免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

COVID-19的致病性涉及线粒体功能障碍和氧化还原失衡.
SARS-CoV-2 流行病造成了全球健康和经济的破坏.
疫苗接种是预防病毒感染的关键策略.

研究的目的:

为了测试预防性疫苗接种是否影响急性COVID-19后的血小板线粒体生物能学.
研究疫苗接种对内源性辅酶Q10 (CoQ10) 生物合成在后急性COVID-19患者的影响.

主要方法:

包括10名接种疫苗后急性COVID-19 (V + PAC19) 患者,10名未接种疫苗 (PAC19) 患者和16名健康对照 (C).
使用高分辨率呼吸计 (HRR) 方法评估血小板线粒体生物能量功能.
通过高性能液体染色学 (HPLC) 量化了CoQ10,托科菲罗尔和β-胡卜素;通过光谱测量测量了TBARS.

主要成果:

接种疫苗显著保护了COVID-19后急性患者的血小板线粒体生物能量功能.
这些患者的内源性辅酶Q10 (CoQ10) 水平没有通过接种疫苗恢复.

结论:

接种SARS-CoV-2疫苗可以防止血小板线粒体呼吸和能量生产的减少.
目前尚不清楚SARS-CoV-2抑制CoQ10水平的确切机制.
HRR和CoQ10确定方法可以帮助监测线粒体生物能学和指导治疗后急性COVID-19.

关键词:

在SARS-CoV-2病毒.抗氧化剂抗氧化剂是一种抗氧化剂.辅酶Q10是一种辅酶.脂质过氧化过氧化线粒体的氧化酸化酸化.血小板血小板是后急性COVID-19后的情况接种疫苗接种疫苗

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