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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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SARS-CoV-2 Omicron 特定突变影响传染性,融合性和部分 TMPRSS2-依赖性

Romano Strobelt1, Karin Broennimann1, Julia Adler1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.

Viruses
|May 27, 2023
PubMed
概括

新的SARS-CoV-2变种,如Omicron,由于特定突变,其传染性降低. 关键的Omicron残留物减少细胞融合和TMPRSS2的依赖性,可能降低疾病的严重程度.

关键词:
这是一种SARS-CoV-2内体感染.在SARS-CoV-2突变病毒中.在病毒感染中TMPRSS2兰蒂-斯派克伪病毒奥米克朗功能性突变体病毒介导的膜融合是病毒的媒介.

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