β-葡萄糖诱导免疫训练,通过激活TBK1来促进抗病毒活性
Guolei Wang1, Zhiqiang Li1, Mingfu Tian2
1Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Viruses
|May 27, 2023
概括
贝塔葡萄糖,以训练有素的对微生物的免疫力而闻名,也可以增强先天的抗病毒防御. 这项研究表明β-葡萄糖促进抗病毒反应并保护肺部,表明其治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物化学 生物化学
背景情况:
- 已知β-葡萄糖可诱导先天性免疫细胞的训练免疫力,通过代谢和表观遗传变化增强对细菌和真菌感染的防御力.
- 贝塔葡萄糖和训练免疫在抗病毒感染中的作用在很大程度上仍未被探索.
研究的目的:
- 研究由Candida albicans和β-葡萄糖诱导的训练免疫在抗病毒天生的免疫力中的作用.
- 探索β-葡萄糖作为治疗病毒感染的治疗剂的潜力.
主要方法:
- 用小鼠巨细胞来评估干扰素-β (IFN-β) 和介质素-6 (IL-6) 的表达,在治疗C. albicans和β-glucan后感染病毒后进行治疗.
- 用β-葡萄糖预处理的小鼠被感染病毒,以评估肺病理和IFN-β表达.
- 通过检查TANK结合激酶1 (TBK1) 的酸化和无化,研究了β-葡萄糖的作用机制.
主要成果:
- β-葡萄糖和C. albicans促进了病毒感染小鼠巨细胞中IFN-β和IL-6的表达.
- 在小鼠中,β-葡萄糖预治疗减少了病毒诱导的肺损伤,并增加了IFN-β的表达.
- 发现β-葡萄糖可以增强TBK1的酸化和无处不在,这是天生的免疫路径的关键组成部分.
结论:
- β-葡萄糖通过增强IFN-β的产生和保护病毒诱导的肺病理促进先天性抗病毒免疫力.
- 该机制涉及TBK1信号通路的调制.
- β-葡萄糖代表了潜在的抗病毒治疗策略的有希望的生物活性物质.
相关概念视频
01:29Immune Response Against Viral Pathogens
837
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
837
01:31Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
01:24B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
01:27Cytotoxic T Cells-mediated Immune Response
1.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.0K
01:40Cell-mediated Immune Responses
69.2K
Overview
69.2K
01:28Cells of the Innate Immune Response
1.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.8K