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相关概念视频

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在儿科阻塞性睡眠呼吸障碍中建模代谢性能:一个病例对照研究.

Francisco Alves de Sousa1, Marta Rios Pinho2, Ana Nóbrega Pinto1

  • 1Otorhinolaryngology and Head & Neck Surgery, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Journal of sleep research
|May 27, 2023
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概括

患有阻塞性睡眠呼吸障碍 (OSDB) 的儿童的休息代谢较高,但运动能力降低. 这项研究模拟了这些代谢变化,突出了儿科患者潜在的心血管影响.

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呼吸暂停 (apnea) 是一种能源支出 能源支出运动就是炼身体.代谢过程中的代谢.阻塞性睡眠 呼吸障碍 呼吸障碍消耗氧气消耗氧气的时间.

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科学领域:

  • 儿童心脏病学 儿童心脏病学
  • 睡眠医学 睡眠医学
  • 运动生理学 运动生理学

背景情况:

  • 儿科阻塞性睡眠呼吸障碍 (OSDB) 显著影响心血管生理学.
  • 对于儿童的基础代谢和运动反应,OSDB对儿童基础代谢和运动反应的影响在很大程度上是未知的.
  • 了解这些代谢后果对于全面的患者护理至关重要.

研究的目的:

  • 估计和建模患有OSDB的儿童的休息和运动代谢.
  • 为了比较带有和没有OSDB的儿童之间的代谢参数.
  • 为儿童群体提供OSDB对生理影响的见解.

主要方法:

  • 对1256名接受耳鼻喉科手术的儿童进行了回顾性病例对照分析.
  • 测量心率 (HR) 的方法.
  • 使用预测方程,估计休息时和运动时的氧气消耗 (VO2) 和能量消耗 (EE).

主要成果:

  • 与对照组相比,患有OSDB的儿童的休息HR,VO2和EE均较高 (p<0.05).
  • 患有OSDB的患者在最大运动期间显示出较低的最大VO2 (VO2max) 和EE (p<0.01).
  • 随着运动增加的VO2和EE (Δ VO2和 Δ EE) 在所有强度的OSDB组显着较低 (p<0.01).

结论:

  • 儿科OSDB与基础代谢率升高有关.
  • 患有OSDB的儿童表现出运动表现受损和心肺呼吸能力下降.
  • 这些发现支持OSDB,新陈代谢变化和儿童心血管功能障碍之间的联系.