在儿科阻塞性睡眠呼吸障碍中建模代谢性能:一个病例对照研究
Francisco Alves de Sousa1, Marta Rios Pinho2, Ana Nóbrega Pinto1
1Otorhinolaryngology and Head & Neck Surgery, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Journal of sleep research
|May 27, 2023
概括
患有阻塞性睡眠呼吸障碍 (OSDB) 的儿童的休息代谢较高,但运动能力降低. 这项研究模拟了这些代谢变化,突出了儿科患者潜在的心血管影响.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 睡眠医学 睡眠医学
- 运动生理学 运动生理学
背景情况:
- 儿科阻塞性睡眠呼吸障碍 (OSDB) 显著影响心血管生理学.
- 对于儿童的基础代谢和运动反应,OSDB对儿童基础代谢和运动反应的影响在很大程度上是未知的.
- 了解这些代谢后果对于全面的患者护理至关重要.
研究的目的:
- 估计和建模患有OSDB的儿童的休息和运动代谢.
- 为了比较带有和没有OSDB的儿童之间的代谢参数.
- 为儿童群体提供OSDB对生理影响的见解.
主要方法:
- 对1256名接受耳鼻喉科手术的儿童进行了回顾性病例对照分析.
- 测量心率 (HR) 的方法.
- 使用预测方程,估计休息时和运动时的氧气消耗 (VO2) 和能量消耗 (EE).
主要成果:
- 与对照组相比,患有OSDB的儿童的休息HR,VO2和EE均较高 (p<0.05).
- 患有OSDB的患者在最大运动期间显示出较低的最大VO2 (VO2max) 和EE (p<0.01).
- 随着运动增加的VO2和EE (Δ VO2和 Δ EE) 在所有强度的OSDB组显着较低 (p<0.01).
结论:
- 儿科OSDB与基础代谢率升高有关.
- 患有OSDB的儿童表现出运动表现受损和心肺呼吸能力下降.
- 这些发现支持OSDB,新陈代谢变化和儿童心血管功能障碍之间的联系.
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