无症状的异常性内高血压:患病率和预后
Mark Thaller1,2,3, Victoria Homer4, Susan P Mollan1,5
1Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Clinical & experimental ophthalmology
|May 27, 2023
概括
偶尔发现患有 papilledema 的异常性内高血压 (IIH) 患者的视觉结果类似,无论是无症状还是有症状. 然而,许多无症状患者在随访期间会出现症状,主要是头痛.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 无症状内高血压 (Idiopathic intracranial hypertension,IIH) 是一种在无症状个体中表现和预后不明确的疾病.
- 乳头,IIH的一个迹象,可以在例行眼科检查期间偶然检测到,许多患者在进一步询问时会出现症状.
研究的目的:
- 为了比较IIH患者的视觉和头痛结果,IIH患者呈现有或没有症状.
- 评估无症状IIH的长期预后.
主要方法:
- 一项前性观察队列研究,涉及343名在2012年至2021年期间被诊断患有IIH的患者,被纳入IIH:Life数据库.
- 使用局部加权散射图平滑图和回归分析评估视觉结果 (LogMAR,Humphrey视野周边平均偏差,光学连贯性断层扫描) 和头痛.
主要成果:
- 在121名偶发发病的患者中,36人在诊断时无症状.
- 与症状患者相比,无症状IIH患者表现出类似的视觉预后.
- 在随访期间,66%的无症状患者出现了症状,头痛是主要症状 (96%),尽管头痛的频率在这个队列中较低.
结论:
- 患有异常性内高血压的个体的视觉预后类似,无论最初的症状状况如何.
- 很大一部分最初无症状的IIH患者会随着时间的推移发展出症状,特别是头痛.
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