基于压力蛋白质的自杀预测得分和与报告的早期生活逆境和最近生活压力的关系
Mark D Underwood1,2, Hanga Galfalvy3,2, Shu-Chi Hsiung1
1Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York, USA.
The international journal of neuropsychopharmacology
|May 27, 2023
概括
早期的逆境 (ELA) 并没有直接影响自杀风险,但最近的生活压力 (RLS) 与HPA轴蛋白相关. 大脑衍生神经营养因子 (BDNF) 失调与特定大脑区域的自杀和ELA有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 分子生物学分子生物学
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴对应激反应至关重要,并与严重抑郁症和自杀有关.
- 早期的逆境 (ELA) 和最近的生活压力 (RLS) 是已知的心理健康状况的风险因素.
- 研究与压力和自杀相关的大脑中的分子变化对于理解病理生理学至关重要.
研究的目的:
- 检查早期生活逆境 (ELA),近期生活压力 (RLS) 和自杀之间的关系.
- 在人脑中分析关键的与压力相关的蛋白质水平,包括皮质激素释放激素 (CRH),FK506结合蛋白 (FKBP5),葡萄糖皮质体受体 (GR) 和脑衍生神经营养因子 (BDNF).
- 为了确定这些分子标记能否预测自杀风险.
主要方法:
- 用心理解剖来评估13个四胞胎 (自杀者和对照) 的ELA,RLS和精神病诊断.
- 在前额叶皮层 (BA9) 和前带皮层 (BA24) 中,CRH,CRH结合蛋白,FKBP5,GR和BDNF的蛋白质水平使用西方斑点在前额叶皮层 (BA9) 和前带皮层 (BA24) 中量化.
- 包括后勤回归在内的统计分析被用来确定自杀的预测因素.
主要成果:
- 在CRH,FKBP5,GR或CRH结合蛋白中没有发现与自杀或ELA相关的显著差异.
- 大脑衍生神经营养因子 (BDNF) 在前带皮层 (BA24) 中显示自杀和ELA之间的相互作用.
- 最近生活压力 (RLS) 在前带皮层的BA9和FKBP5中与CRH负相关. 在BA24中BDNF,GR和FKBP5的组合预测了71%的灵敏度和特异性的自杀.
结论:
- 虽然HPA轴在自杀中通常是失调的,但ELA与这些特定蛋白质变化没有直接联系.
- 最近生活压力 (RLS) 显示与特定大脑区域的某些HPA轴蛋白有关.
- 大脑衍生神经营养因子 (BDNF) 在ELA和自杀的背景下,似乎以特定区域的方式受到失调.
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