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青少年多囊性卵巢综合征诊断特征的规范性切断值使用集群分析

Sylvia Kiconco¹, Arul Earnest², Joanne Enticott¹

¹Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3800, Australia.

European journal of endocrinology

|May 27, 2023

概括

这项研究使用了集群分析来确定青少年多囊性卵巢综合征 (PCOS) 的新诊断标准,发现截止值比以前使用的更低. 这些发现表明,需要重新定义青少年PCOS诊断标准.

科学领域:

生殖内分泌学生殖内分泌学
儿科内分泌学儿科内分泌学
临床诊断临床诊断临床诊断

背景情况:

诊断多囊卵巢综合征 (PCOS) 是具有挑战性的,因为它依赖于随意的百分点切断值来诊断特征.
目前的PCOS诊断标准缺乏准确性,受到可变的实验室范围和不良特征的人群的影响.
群集分析被推用于定义特定人群的规范性截止值,但它在PCOS研究中未得到充分利用,特别是在青少年中.

研究的目的:

在社区青少年群体中确定PCOS诊断关键特征的规范性切断值.
应用集群分析来确定青少年的确切诊断值.
将新定义的切断值与青少年PCOS诊断常规标准进行比较.

主要方法:

利用了来自青少年月经研究的数据,这是244名青少年 (平均年龄15.2岁) 的前队列.
使用的k-平均集群分析和接收器运行特征 (ROC) 曲线.
定义了修改后的费里曼-加尔维 (mFG) 评分,自由 (自由T),自由雄激素指数 (FAI) 和月经周期长度的规范性截止值.

主要成果:

确立的规范性切线:mFG得分≤1.0,自由T≤23.4 pmol/L,FAI≤3.6,月经周期长度≤29天.
这些切断线分别对应于人口百分比的第65,71,70和59位.
导出的切线值低于用于PCOS诊断的传统值.

结论:

新的规范性诊断标准被定义为未经选择的青少年群体的切断点.
该研究强调,目前的PCOS诊断截止值可能对青少年来说过高.
对青少年PCOS诊断标准的重新定义是必要的,需要在更大,更多样化的队列中进行验证.

关键词:

在PCOS中,PCOS是PCOS.青少年青少年青少年集群分析集群分析集群分析截止时间截止时间诊断诊断诊断诊断诊断诊断

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