开发和在功能研究的双特异性持续释放药物载入的纳米脂质体肝细胞癌的肝细胞癌
Yufei Zhang1, Xiaoxiong Wu1, Hongfan Zhu1
1Shanghai Seventh People's Hospital, Shanghai, China.
Journal of biomaterials applications
|May 27, 2023
概括
研究人员开发了双向的磁性纳米脂质体 (MNL) 来为肝细胞癌 (HCC) 提供伦瓦替尼 (LEN). 这些MNL显示了特定的向,有效的药物输送和MRI追踪能力,以改善HCC诊断和治疗.
科学领域:
- 纳米医学是一种纳米医学.
- 生物技术是生物技术.
- 在瘤学瘤学.
背景情况:
- 伦瓦提尼布 (LEN) 是肝细胞癌 (HCC) 的一线治疗方法.
- LEN具有显著的不良影响概况.
- 需要新的药物输送系统来改善HCC治疗.
研究的目的:
- 开发一种具有携带药物和MRI成像功能的脂质体,用于HCC.
- 为了研究向药物输送和MRI追踪能力的脂质体的HCC.
主要方法:
- 准备好的磁性纳米脂质体 (MNL) 具有双重向 (EpCAM和维丁) 封装LEN.
- 以性能,药物负载和细胞毒性为特征的EpCAM/vimentin-LEN-MNL.
- 在细胞和动物模型中研究了双重准,缓慢释放和MRI追踪.
主要成果:
- EpCAM/vimentin-LEN-MNL显示了最佳的粒子大小,潜力和分散.
- 实现了高封装率 (92.66%) 和药物加载率 (9.35%).
- 证明了低细胞毒性,有效的HCC抑制,细胞亡促进和MRI追踪的特定向.
结论:
- 成功开发了一种特定于HCC的双重向的持续释放脂质体,并配备了MRI追踪器.
- 脂质体显示双重目标识别和敏感的MRI追踪.
- 在瘤诊断和治疗中最大限度地发挥纳米载体效应的基础.
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