患有类风湿性关节炎的患者中患病率和与多种药物相关的因素:一个单中心的横截面研究
Hirofumi Miyake1, Ryuichi Minoda Sada2,3,4, Hiroyuki Akebo2
1Department of General Internal Medicine, Tenri Hospital, 200 Mishima, Tenri, Nara, 632-8552, Japan. hmiyake1623@gmail.com.
Clinical rheumatology
|May 27, 2023
概括
多药性影响了61%的类风湿性关节炎患者,15%的患者经历过多药性治疗. 住院史和葡萄糖皮质激素的使用是关键的因素,需要药物审查和停止使用类固醇.
科学领域:
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 多药性,定义为定期使用五种或以上的口服药物,在治疗诸如类风湿性关节炎等慢性疾病方面越来越令人担忧.
- 识别与多药学相关的因素对于优化患者护理和减少不良事件至关重要.
研究的目的:
- 在类风湿性关节炎患者中调查多药和过度多药 (10+口服药物) 的患病率.
- 为了确定临床,社会和医疗保健利用因素与多药在这个人群中.
主要方法:
- 进行了一项单一中心的横截面研究,涉及991名类风湿性关节炎患者.
- 数据收集包括药物使用,健康评估问卷残疾指数,查尔森并发症指数和住院史.
- 统计分析确定了与多药和过度多药相关的因素.
主要成果:
- 多药性在61%的患者中普遍存在,过度多药性在15%的患者中普遍存在.
- 与多药学相关的因素包括年龄较大,残疾程度较高 (HAQ-DI),使用葡萄糖皮质体和并发症 (查尔森指数).
- 住院史和访问其他内科诊所是显著的预测因素. 过度的多药也与公共援助有关.
结论:
- 多药和过度多药在类风湿性关节炎患者中很常见.
- 住院史和葡萄糖皮质激素使用是需要注意的重大风险因素.
- 建议包括审查住院治疗的药物,并考虑停止葡萄糖皮质类药物以减轻多药性.
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