最近和先进的治疗口腔癌的治疗方法
Gomathy Baskar1, Thirunavukkarasu Palaniyandi1,2, Sandhiya Viswanathan1
1Department of Biotechnology, Dr. M.G.R. Educational and Research Institute, Deemed to be University, Chennai, India.
Biotechnology and bioengineering
|May 27, 2023
概括
三维 (3D) 细胞培养模型为研究口腔癌提供先进的体外方法,改进传统模型并帮助纳米粒子药物递送研究.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 纳米技术纳米技术
背景情况:
- 口腔癌是一种流行且致命的恶性瘤,死亡率高,通常影响40岁以上的成年人.
- 传统的体外方法,如单层细胞培养和动物模型,在准确模仿人类口腔癌方面存在局限性.
- 有一个全球性的倡议减少动物试验,推动了更具预测性的与人类相关的体外模型的需求.
研究的目的:
- 对口腔癌研究的3D细胞培养模型的当前进展进行审查.
- 探索这些模型在评估基于纳米粒子的药物输送系统中的应用.
- 突出3D文化在理解口腔癌遗传学和药物发现方面的作用.
主要方法:
- 关于各种3D细胞培养技术的文献综述,包括多细胞球体,患者衍生式外置物,器官体,外移植,3D生物打印和芯片上的器官体.
- 用2D和3D培养在基于纳米粒子的口腔癌药物发现中的研究分析.
- 讨论3D模型在复制本地组织架构和细胞相互作用方面的优势.
主要成果:
- 3D细胞培养模型在模仿口腔瘤复杂的微环境方面显示出显著的潜力.
- 这些模型为评估纳米粒子药物递送系统的有效性和机制提供了一个更准确的平台.
- 3D培养促进了对口腔癌中的基因功能和治疗点的更深入的理解.
结论:
- 先进的3D细胞培养模型对于开发有效的基于纳米粒子的治疗方法来治疗口腔癌至关重要.
- 这些模型代表了传统方法的有希望的替代方案,提供了增强的生理相关性和减少对动物试验的依赖.
- 3D培养技术的持续开发和应用将加速口腔癌药物发现和个性化治疗策略.
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