肥胖和外周动脉疾病:当前的证据和争议
Ioannis G Lempesis1, Dimitrios Varrias2, Marios Sagris3
1Department of Biologic Chemistry, School of Medicine, National and Kapodistrian, University of Athens, Mikras Asias 75, 115 27, Athens, Greece. lemp.ioan@gmail.com.
Current obesity reports
|May 27, 2023
概括
肥胖悖论表明,较高的体重可能会防止周围动脉疾病 (PAD) 的并发症和死亡率. 本综述探讨了肥胖和PAD之间的有争议的联系,包括潜在的保护机制.
科学领域:
- 心血管医学 心血管医学
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖是一个主要的公共卫生问题,也是动脉样硬化风险因素.
- 周围动脉疾病 (PAD) 影响西方人口的3%-10%,导致严重的结果.
- 肥胖和PAD之间的关系是有争议的,一些研究表明有保护作用 (肥胖悖论).
研究的目的:
- 审查肥胖和PAD发展,进展和管理之间的关联.
- 讨论潜在的病理生理机制,将肥胖与PAD联系起来.
- 检查围绕肥胖对PAD影响的有争议的证据.
主要方法:
- 对现有文献和元分析进行系统审查.
- 对研究研究肥胖悖论在PAD的分析.
- 探索遗传,脂肪组织和身体脂肪分布因素.
主要成果:
- 最近的元分析表明,较高的体重指数可能有助于预防PAD并发症和死亡率.
- 肥胖作为PAD发展的危险因素的证据是有争议的.
- 潜在的机制包括遗传背景,脂肪组织功能障碍和身体脂肪分布.
结论:
- 肥胖在PAD发展和进展中的作用仍然存在争议.
- 较高的体重指数可能会提供保护,防止PAD相关的死亡率.
- 需要进一步的研究来阐明复杂的关系和潜在的机制.
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