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在小儿霍奇金淋巴瘤化疗后的反弹胸膜激增和胸膜复发之间的区别

Friedrich Christian Franke¹, Adrian Damek², Jonas Steglich²

¹Department of Radiology, Diakoniekrankenhaus Halle, Halle (Saale), Germany.

Pediatric blood & cancer

|May 27, 2023

概括

儿童淋巴瘤的化疗后,反弹胸膜增生 (RTH) 是常见的. 区分RTH与胸膜淋巴瘤复发 (LR) 是至关重要的;孤立的胸膜生长表明RTH,而外胸膜质量表明LR.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
儿科血液瘤学

背景情况:

反弹胸膜增生 (RTH) 是儿科淋巴瘤患者治疗后经常出现的现象.
将RTH误诊为胸腺淋巴瘤复发 (LR) 可能导致不必要的干预.
准确区分RTH和胸膜LR对于适当的患者管理至关重要.

研究的目的:

在儿科古典霍奇金淋巴瘤 (CHL) 患者中识别将RTH与胸膜LR区分开来的成像参数.
为了减少误诊率,避免过度治疗.
在化疗后改善前半中部的诊断准确度.

主要方法:

对291名儿科CHL患者化学治疗后CT和MRI扫描的分析.
评估胸膜区域形态,化和质量存在.
在活检证明的LR病例中评估异位淋巴瘤复发 (LR) 症状和FDG-PET-CT.

主要成果:

在291名患者中,有133名患者在化疗后表现出胸腔空间质量增加.
没有单一的胸膜再生特征可以在没有活检的情况下区分RTH和LR.
胸膜LR病例 (33/34) 主要表现出额外的胸膜外质量,而RTH病例 (64/64) 呈现出孤立的胸膜生长.

结论:

孤立的胸膜LR在儿科CHL中很少见.
怀疑CHL复发,如果越来越多的群体被发现在胸腺外.
化疗后隔离的胸膜质量可能表明RTH,如果排除了外胸膜复发.

关键词:

18F-FDG-PET-PET的使用情况霍奇金淋巴瘤是一种霍奇金淋巴瘤.计算机断层扫描 (CT) 是一种计算机断层扫描.这是一个复发的复发.胸腺 (thymus) 是一个神经系统.一个X射线.

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