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在两个核心实验室之间使用三维定量冠状动脉血管学三维定量冠状动脉血管学之间的壁切应力分布的协议

Shigetaka Kageyama¹, Vincenzo Tufaro^2,3,4, Ryo Torii⁵

¹Department of Cardiology, University of Galway, College of Medicine, Nursing and Health Sciences, Galway, Ireland.

The international journal of cardiovascular imaging

|May 27, 2023

概括

从3D-QCA计算墙壁剪切应力 (WSS) 的新软件显示了核心实验室之间的高可重现性. 这一进步有助于识别高风险的冠状动脉病变,并改善了WSS分析的临床采用.

科学领域:

心血管成像 - 心血管成像
生物医学工程生物医学工程
计算流体动力学的流体动力学.

背景情况:

从静脉内成像和3D定量冠状动脉血管学 (3D-QCA) 的壁切应力 (WSS) 分析为识别高风险冠状动脉病变提供了预后价值.
目前的WSS分析方法耗时,需要专门的专业知识,阻碍了广泛的临床应用.

研究的目的:

评估一种新型软件的核心间实验室可重复性,用于实时计算时间平均WSS (TAWSS) 和多方向WSS分布.
评估软件能够重复识别具有不利血液动力学和高风险形态的病变的能力.

主要方法:

使用CAAS工作站WSS原型分析了60个冠状动脉病变,包括20个分叉,具有边界分流储量.
两个独立的核心实验室进行了WSS分析,并对3毫米段的估计进行了比较.
类内相关性 (ICC) 和科恩卡帕 (κ) 用于评估各种WSS指标和病变特征的一致性.

主要成果:

在核心实验室之间观察到3D-QCA和TAWSS指标的高ICC值 (0.89-0.92),无论病变位置 (分叉或非分叉).
在多向WSS指标中发现了良好中等的ICC (0.72-0.86).
在检测具有不利血液动力学 (WSS> 8.24 Pa, κ = 0.77) 和高风险形态 (区域狭窄> 61.3%, κ = 0.71) 的病变方面达到了高度一致.

结论:

该CAAS工作站WSS软件可以实现可重复的3D-QCA重建和WSS度量计算.
该软件展示了基于血液动力学和形态学标准可靠识别高风险冠状动脉病变的潜力.
需要进一步的研究,以充分探索该软件在检测高风险病变方面的临床实用性.

关键词:

计算流体动力学的流体动力学.定量冠状动脉血管学定量冠状动脉血管学可复制性可复制性墙壁剪切应力压力是什么

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