在接受脏移植的接受者中,PCV13和PPSV23连续接种疫苗后的抗体反应
Nils Mülling1, Lukas van de Sand2, Kim Völk1,2,3
1Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Infection
|May 27, 2023
概括
在接受脏移植的接受者中,用肺炎球菌合疫苗 (PCV13) 和多糖疫苗 (PPSV23) 连续接种疫苗可以显著提高抗体水平. 这种方法优于单次免疫接种,可以预防侵袭性肺炎球菌疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 疫苗学 疫苗学 疫苗学
背景情况:
- * 肺炎链球菌感染对移植受体构成重大风险.
- *目前的指导方针建议对脏移植患者进行连续性肺炎球菌疫苗接种 (PCV13跟随PPSV23接种).
- * 有限的数据存在于这种人群中对PCV13和PPSV23接种疫苗的血清反应.
研究的目的:
- * 评估移植患者对PCV13和PPSV23接种疫苗的血清反应.
- * 为了比较顺序接种疫苗所获得的抗体水平与单次PCV13疫苗接种的历史数据.
主要方法:
- *46名脏移植接受者接种了PCV13和PPSV23接种疫苗.
- * 全球和特定于血清型的抗肺炎球菌抗体反应在接种疫苗后12个月内被测量.
主要成果:
- *观察到血清型特异性 (2.2-2.9倍) 和全球抗肺炎球菌抗体度的显著增加.
- * 抗体反应因血清型而异,对9N和14血清型的抗体反应增强最强.
- *IgG2的增加率最高 (2.7倍),而IgM的增加率最低 (1.7倍).
- * 顺序接种疫苗产生的抗体水平比单独PCV13更高.
- *在随访期间,没有出现肺炎球菌性肺炎或与疫苗相关的异位移植排斥病例.
结论:
- * 用PCV13和PPSV23进行顺序接种疫苗在加强移植患者抗肺炎球菌抗体反应方面非常有效.
- * 建议采用这种疫苗接种策略,而不是单次免疫接种,以获得更好的保护.
- *这种方法是安全的,没有观察到与疫苗有关的并发症.
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