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在极度早产的儿童中,在6.5至12岁之间发生非最佳神经状况的发生率的变化

Daniela Nosko¹, Lina Broström², Jenny Bolk³

¹Paediatric Department, Örebro University Hospital, Örebro, Sweden.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

|May 27, 2023

概括

极度早产 (EPT) 的儿童在青春期出现的非最佳神经状况和运动功能受损的患病率更高. 虽然神经系统疾病随着年龄的增长而改善,但它们在EPT儿童中仍然比按期出生的同龄人更常见.

科学领域:

儿科神经学儿科神经学
发育儿科发育儿科
神经科学是一个神经科学.

背景情况:

极度早产 (EPT) 与神经发育挑战的风险增加有关.
对EPT儿童的神经状况和运动功能的纵向评估对于理解发育轨迹至关重要.
非最佳的神经状况会影响儿童发育和日常活动的各个方面.

研究的目的:

确定极早早产 (EPT) 到青春期早期的儿童中非最佳神经疾病的患病率.
调查EPT儿童的神经状况和运动功能之间的关联.
为了检查6.5岁至12岁之间神经状况的变化.

主要方法:

前性队列研究包括106名儿童 (62名EPT,44名出生后对照).
在6.5岁和12岁时使用Touwen神经检查的四个领域评估的神经状况.
使用儿童运动评估电池第二版 (MABC-2) 评估的运动功能.

主要成果:

在12岁时,44%的EPT儿童有非最佳的神经状况,而对照组只有9% (p<0.001).
在EPT儿童中,非最佳神经状况的患病率在6.5至12岁之间从37降至27 (p=0.007).
12岁时非最佳神经系统的EPT儿童在总和子尺度测量 (手工敏捷性,准/捕获,平衡) 中的MABC-2得分明显较低.

结论:

非最佳神经系统状况的患病率随着年龄的增长而下降,但在EPT儿童12岁时仍然显著增加.
在EPT儿童中,神经功能障碍与运动功能减弱有关.
在EPT群体中,对神经和运动缺陷的早期识别和干预是有必要的.

关键词:

非常早产的非常早产的轻微的神经功能障碍轻微的神经功能障碍运动器功能运动器功能神经发育神经发育神经功能障碍的神经功能障碍流行程度流行程度

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