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对于患有2型糖尿病的口腔状细胞癌患者的预后模型
Xin Hu1, Haofeng Xiong1, Shiying Huang1
1Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South University, Changsha, China.
一个新的预后模型准确地预测了2型糖尿病口腔状细胞癌患者的结果,识别了T阶段,N阶段和血糖水平等关键因素.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 医学统计 医学统计
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 2型糖尿病 (T2DM) 越来越普遍,可能会影响OSCC的预后.
- 对于患有T2DM的OSCC患者,需要准确的预后工具.
研究的目的:
- 开发和验证OSCCT2DM患者的预后模型.
- 确定影响该患者队列生存的独立预后因素.
主要方法:
- 在雅医院对OSCCT2DM患者进行了回顾性研究.
- 数据分为训练 (n=146) 和测试 (n=81) 集.
- 单变量/多变量考克斯回归和名图构造用于模型开发和验证.
主要成果:
- 确定了六个独立的预后因素:T阶段,N阶段,病理等级,甲胺使用,硫基氨基酸使用和禁食血糖.
- 构建了一个名ogram,实现C指数为0.728.8.
- 该模型证明了对一年生存率的良好预测效率,并将患者分为不同的生存组.
结论:
- 开发的预后模型提供了一种可靠的方法,用于在T2DM的背景下预测OSCC患者的结果.
- 该模型可以帮助临床医生进行风险分层和个性化治疗规划.
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