白色和棕色脂肪组织的循环控制
Kaiming Yue1, Patrick Cn Rensen1, Sander Kooijman1
1Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Current opinion in genetics & development
|May 27, 2023
概括
脂肪组织中循环节律的扰乱会增加心脏代谢疾病的风险. 时间疗法等策略可以通过优化身体内部时钟和确定新的治疗点来减轻这种风险.
科学领域:
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
背景情况:
- 脂肪组织 (白色和棕色) 是动态的器官,应对环境线索.
- 昼夜计时系统对于预测环境变化至关重要.
- 在现代社会中常见的循环节障碍增加了心脏代谢疾病的风险.
研究的目的:
- 审查缓解昼夜干扰引起疾病风险的机制和策略.
- 探索了解脂肪组织中昼夜节律的机会.
- 讨论应用程序,如时间疗法和新的治疗目标.
主要方法:
- 现有文献的小型综述.
- 分析连接昼夜节律和脂肪组织功能的机制.
- 讨论疾病缓解策略.
主要成果:
- 脂肪组织的循环节障碍有助于代谢疾病.
- 时间疗法和优化内源节律是潜在的干预措施.
- 了解脂肪组织的昼夜生物学可以揭示新的治疗点.
结论:
- 了解脂肪组织中的昼夜节律是预防和治疗代谢疾病的关键.
- 针对昼夜时间的干预措施提供了有前途的治疗途径.
- 对脂肪组织昼夜生物学的进一步研究可以导致新的治疗方法.
更多相关视频
04:46Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
1.5K
08:31Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
3.1K
相关概念视频
Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Hypodermis
4.7K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.7K
