在ECMO支持期间使用aPTT引导的抗凝血监测:系统性审查和元分析
Sasa Rajsic1, Benedikt Treml1, Dragana Jadzic2
1Department of Anesthesiology and Intensive Care Medicine, Medical University Innsbruck, Innsbruck 6020, Austria.
Journal of critical care
|May 27, 2023
概括
在体外膜氧化 (ECMO) 期间对抗凝血的监测至关重要,但目前的激活部分血栓形成时间 (aPTT) 指导缺乏确的证据. 需要进行进一步的试验,以确定ECMO患者的最佳抗凝血监测策略,以减少出血风险.
科学领域:
- 心血管科学 心血管科学
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- 由于复杂的凝血和炎症过程,体外膜氧化 (ECMO) 需要抗凝血.
- 系统性抗凝药具有严重出血的重大风险,强调有效监测的重要性.
- 本研究研究了抗凝血监测实践与ECMO治疗患者出血发生的关系.
结论:
- 激活部分血栓形成时间 (aPTT) 引导的抗凝药仍然是ECMO患者的标准,尽管缺乏支持其在监测中的有效性强有力的证据.
- 目前的证据并不强烈支持在ECMO期间使用PTT引导的监测.
- 进一步的随机试验对于确定ECMO最佳抗凝血监测策略至关重要,以改善患者的治疗结果并减少出血并发症.
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