丸激素对精子参数和新鲜和解的norm和asthenozoospermic样本中的染色质状态的治疗潜力
Masoomeh Mohammadzadeh1, Fateme Montazeri2, Jafar Poodineh3
1Department of Reproductive Biology, Yazd Reproductive Sciences Institute, Research and Clinical Center for Infertility, and Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Revista internacional de andrologia
|May 27, 2023
概括
低剂量的丸激素对正常和不孕男性的精子染色质量产生积极影响. 这一发现为与氧化应激相关的男性不孕症提供了潜在的治疗策略.
科学领域:
- 生殖生物学 生殖生物学
- 安德罗学与人类学
- 氧化应激研究研究 氧化应激研究
背景情况:
- 荷尔蒙波动可以提高反应性氧物种 (ROS),导致氧化应激并导致男性不孕.
- 大约25%的男性不孕不育病例归因于荷尔蒙缺乏,环境和其他因素,而ROS是无法解释的不孕不育的主要原因.
- 有限的研究存在于丸激素对人类精子培养的特定影响.
研究的目的:
- 为了研究不同度的丸激素对人类精子参数的影响.
- 评估丸激素对精子染色质量和原氨基化的影响.
主要方法:
- 从正常精子和精子患者的精液样本被分成组,并暴露在1,10,或100nM的45分钟.
- 在冷前和解后 (储存两周后) 评估了精子参数和染色质前化.
- 微精子形态学 (MSOM) 技术用于评估精子形态学.
主要成果:
- 在冷前或冷后,丸激素暴露并没有显著改变任何组的精子参数.
- 在接受10nM丸激素 (冷前) 和1nM或10nM丸激素 (解后) 治疗的正态精子样本中,染色质原胺显著降低.
- 阿斯精子样本显示,在结前和解后,随着1nM或10nM丸激素的暴露,染色质质质量显著降低.
结论:
- 低剂量 (1nM和10nM) 对精子染色质量产生积极影响.
- 可能在改善染色质完整性方面发挥作用,可能减轻与氧化应激相关的不孕症.
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