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瘤微环境的胆固醇图谱为改善CAR-T治疗提供了途径

Adriano B Chaves-Filho1, Almut Schulze2

  • 1Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508000, Brazil.

Cancer cell
|May 27, 2023
PubMed
概括

瘤内胆固醇缺乏会通过抑制mTORC1信号来降低细胞毒性T细胞的抗癌活性. 通过肝脏X受体 (LXR) 阻断,在仿真抗原受体 (CAR) -T细胞中增加胆固醇可以增强抗瘤功能.

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