2022年阿西西智库会议:关于优化乳腺癌辐射治疗的白皮书
C Aristei1, O Kaidar-Person2, L Boersma3
1Radiation Oncology Section, Department of Medicine and Surgery, University of Perugia and Perugia General Hospital, Perugia, Italy.
Critical reviews in oncology/hematology
|May 27, 2023
概括
本综述强调了乳腺癌治疗的主要挑战,重点关注节点参与的放射治疗 (RT) 和结合RT与免疫治疗. 专家建议,针对局部复发的再照射可能涉及部分乳房照射.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 第四届阿西西智库会议召开专家会议,审查当前的乳腺癌数据和研究建议.
- 通过在线问卷识别了临床挑战,不到70%的专家同意.
研究的目的:
- 确定和讨论乳腺癌管理中的关键临床挑战,特别是关于放射治疗 (RT) 和免疫治疗 (IT) 的问题.
- 审查正在进行的研究和研究建议,解决这些挑战,并探索乳腺癌治疗的未来方向.
主要方法:
- 审查最新数据,正在进行的研究和研究建议.
- 分析专家的在线问卷答复,以确定临床分歧的领域.
主要成果:
- 关键的挑战包括特定患者亚组的节点RT (例如,没有带淋巴结解剖的阳性哨兵节点,在新辅助疗法后的节点阳性疾病).
- RT和免疫治疗的最佳组合,包括患者选择,时间,剂量和目标体积,仍然是研究领域;然而,联合毒性不被认为是增强的.
- 针对局部复发的再照射表明,在重复的乳房保护手术后进行部分乳房照射,高热症显示有希望但可用性有限.
结论:
- 在优化节点辐射疗法和在乳腺癌治疗中将免疫疗法与辐射疗法结合在一起方面,仍然存在重大临床挑战.
- 进一步的研究对于完善再照射策略的最佳实践至关重要,特别是部分乳腺照射,用于管理局部乳腺癌复发.
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