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在amycolatopsis菌株中,shikimate通路的代谢工程用于优化糖抗生素生产

Valentina Goldfinger1, Marius Spohn1, Jens-Peter Rodler2

  • 1Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbiology/Biotechnology, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.

Metabolic engineering
|May 27, 2023
PubMed
概括

控制糖抗生素 (GPA) 生产中的shikimate通路是关键. 在Amycolatopsis balhimycina中过度表达特定的酶显著提高了巴尔希米产量,证明了可行的代谢工程策略.

关键词:
芳香氨基酸是一种芳香氨基酸.巴尔希米辛 (Balhimycin) 是一种药物.他们的GPA高.路径工程工程的路径工程.前身优化的前身优化里斯托米辛是一种菌素.石基马特通道的路径

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