绘制草本有机化合物对肠道细菌的调节效应
Yulong Zhang1, Ting Chen1, Xiaoqing Hao2
1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410078, P. R. China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
Pharmacological research
|May 27, 2023
概括
测试的近三分之一的草本有机化合物 (HOC) 显示出肠道细菌活性. 特定的化合物,如子是强大的,影响肠道微生物群,并可能改善健康结果,如胰岛素抵抗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 自然产品 化学 化学
背景情况:
- 来自药用植物和中国传统医药 (TCM) 的草本有机化合物 (HOC) 是生物活性.
- 高合物对肠道微生物群的影响,特别是那些具有低生物可用性的人,尚未完全理解.
研究的目的:
- 系统地选HOC对抗肠道细菌的抗共生活性.
- 为了识别与HOC反共生活动相关的化学特征和分子描述符.
- 研究HOCs在调节肠道微生物群的治疗潜力,以获得健康益处.
主要方法:
- 在实验室中对481种HOC对47种肠道细菌菌株进行查.
- 对HOC对人类便微生物群概况影响的分析.
- 使用随机森林,对分子和化学特征与反共生活动的相关性分析.
- 在高脂肪饮食 (HFD) 鼠标模型中使用黄素进行体内验证.
主要成果:
- 大约30%的选HOCs表现出反共生活动.
- 昆显示出强烈的活性;和脂肪酸抑制了Lactobacillus.
- 立体化学 (S-配置) 影响了抗共生功效.
- 对便微生物群的HOC影响与体外菌株活性相关.
- 库尔库调节肠道微生物群以改善HFD小鼠的胰岛素耐药性.
结论:
- 很大一部分高氧化具有对肠道细菌的直接抗共生活性.
- 分子和化学特性预测HOCs对肠道微生物群的影响.
- HOCs可以调节肠道微生物群的组成和功能,为代谢性疾病提供治疗潜力.
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