在BNT162b2增剂接种疫苗后,反应性和免疫性之间的关联:对前性队列研究的二次分析
Anselm Jorda1, Felix Bergmann2, Robin Ristl3
1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
概括
针对COVID-19的补充疫苗接种显示,系统症状和抗体水平之间存在较弱的相关性. 自我报告的症状严重程度不能预测增强剂后的免疫性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,症状严重程度和COVID-19初级免疫接种后抗体水平之间存在弱相关性.
- 了解反应性和免疫性对于评估疫苗有效性和公共卫生战略至关重要.
研究的目的:
- 为了调查反应性 (症状) 和免疫性 (抗体水平) 之间的关联,在针对COVID-19进行强剂疫苗接种后.
- 为了确定增强剂后自我报告的症状是否可以预测抗体反应.
主要方法:
- 一项前性队列研究的二次分析,涉及484名接受BNT162b2COVID-19强剂疫苗的医疗保健工作者.
- 疫苗接种前和28天后的抗体水平评估的抗受体结合域 (RBD) 抗体水平.
- 在补充剂后7天内收集每日关于局部和全身副作用严重性的数据.
- 利用斯皮尔曼相关性来分析症状严重程度和抗体水平之间的关系,用于多次比较使用邦费罗尼校正.
主要成果:
- 大多数参与者 (93.2%局部,90.3%全身) 报告了后复发症状.
- 在局部症状的严重程度和抗体水平之间没有发现相关性.
- 在几个系统性症状 (疲劳,发烧,头痛,关节痛,肌痛) 和28天抗RBD抗体水平之间观察到弱但具有统计学意义的相关性.
- 在后增剂症状和前增剂抗体水平之间没有发现任何关联.
结论:
- 在COVID-19增剂接种疫苗接种后出现的全身症状的严重程度和28天后测量的抗体水平之间存在微弱的相关性.
- 自我报告的症状严重程度不是继补充疫苗接种后免疫性可靠的预测指标.
- 进一步的研究可能会探索影响疫苗反应和症状感知的其他因素.
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